Fresh analysis reveals that patients who discontinue popular slimming jabs like semaglutide or tirzepatide tend to recover reduced body mass much more quickly than those who stop conventional diet and exercise programs.
Published data in a major medical journal demonstrates that while overweight people frequently drop substantial amounts of their body weight while undergoing treatment, the mass is regained at an average rate of nearly a kilo each month upon discontinuation.
"People buying these drugs need to be cognizant of the risk of quick weight regain when the treatment is stopped," warns researcher Dr. Susan Jebb.
That rate of regain suggests a reversion to original weight in about one and a half years.
Weighing Therapies
The research, which reviewed 37 of trials involving thousands of patients, contrasted the outcomes of the injectable medications with other pills.
The team emphasize that individuals who lose weight through dieting usually have a slower weight regain—approximately 100 grams monthly—once they finish.
The Reason for the Fast Regain
Nutrition scientists suggest the mode of action of the jabs accounts for the amplified weight return.
GLP-1 drugs mimic a body's own chemical called GLP-1, which moderates hunger.
"Artificially providing the hormone levels far above than the body's typical production could lead to the system to generate a reduced amount of its own natural GLP-1, and could reduce sensitivity to its actions," noted Dr. Adam Collins, a dietetics expert.
"Withdrawal of this hormone supplement results in hunger is no longer kept in check, making overeating much more probable."
A Chronic Condition?
The NHS recommend the jabs for individuals with obesity-related health risks, accompanied by prescribed lifestyle changes.
Many experts say that, given the likelihood of relapse, the treatment is often long-term.
This view is echoed by drug manufacturers, who say that the results "emphasize the long-term nature of excess weight," akin to managing conditions like diabetes.
User Testimonies
People who have come off the medication explain a powerful return of hunger.
"It felt as if a switch that goes on and I was suddenly ravenous," described a patient.
The struggle is compounded if patients have not adopted permanent lifestyle or habit modifications during therapy.
Widespread Adoption
Survey data show that a significant number of people in the UK have tried these injections in the last 12 months, with desire being substantial.
- Adoption is greater among females compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many access the drugs through private prescriptions rather than the NHS.
Ultimately, experts caution that while these medications are potent agents for weight loss, they are not a magic fix and lasting health benefits likely depends on integrated lifestyle management.
